Where NutriPhenomics Begins
© 2006 Research Diets, Inc. All rights reserved. D12492--2-13
Rodent Diet with 60% kcal% fat.
Used in Research
Fatty Liver In ammation Obesity Diabetes
Packaging
Product is packed in 12.5 kg box.Each box is identi ed with the product name, description, lot number and expiration date.
Lead Time
IN-STOCK.
Ready for next day shipment.
Gamma-Irradiation
Yes. Add 10 days to delivery time.
Form
Pellet, Powder, Liquid
Shelf Life
Most diets require storage in a cool dry environment. Stored correctly they should last 6 months.
Because of the high fat content is best if kept frozen.
Control Diets
D12450B, D12450J, D12450K
Formula
Product #D12492
gm%Protein 26.2
Carbohydrate 26.3Fat 34.9 Total kcal/gm
5.24
Ingredient
gm
Casein, 30 Mesh
200L-Cystine
3Corn Starch 0Maltodextrin 10 125Sucrose 68.8Cellulose, BW200 50Soybean Oil 25Lard*
245Mineral Mix S10026 10DiCalcium Phosphate 13Calcium Carbonate
5.5Potassium Citrate, 1 H2O 1
6.5Vitamin Mix V10001
10Choline Bitartrate
2FD&C Blue Dye #1
0.05
Total
773.85
kcal%
202060100
kcal
800120500275.2
022********
40004057
Formulated by E. A. Ulman, Ph.D., Research Diets, Inc., 8/26/98and 3/11/99.
*Typical analysis of cholesterol in lard = 0.72 mg/gram.Cholesterol (mg)/4057 kcal = 216.4Cholesterol (mg)/kg = 279.6
D12450B, D12451, D12492 The "Original High Fat Diets"
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a mutated serotonin 5-HT2C receptor gene. Nature Medicine 1998; 4:1152-1156.
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with diet-induced obesity. J.Clin.Invest. 2000; 105:1827-1832.
5. Bush EN, et al.(Metabolic Disease Research, Abbott Laboratories) Adiposity, Leptin
Resistance, Hyperrphagia, Hyperglycemia, Glucose Intolerance and Insulin Resistance in C57BL/6J Mice Fed High Fat Diets.Endocrine SocietyAnnual Meeting 2001,
Poster Session.
6. Shapiro ME, et al. (Metabolic Disease Research, Abbott Laboratories) Effects of
T reatment of C57BL/6j Mice Fed High vs. Low Fat Diets with Metformin or
Rosiglitazone on Adiposity, Food Intake, Hyperglycemia and Insulin Resistance.
Endocrine Society Annual Meeting 2001, Poster Session.
7. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A
T ransgenic Model of Visceral Obesity and the Metabolic Syndrome. Science. 2001;
294:2166-2170.
8. Razani B, Combs TP, Wang XB, Frank PG, Park DS, Russell RG, Li M, Tang B, Jelicks
LA, Scherer PE, Lisanti MP. Caveolin-1 deficient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities. J. Biol. Chem.
2001; (in press).
9. Valet P, Grujic D, Wade J, Ito M, Zingaretti MC, Soloveva V, Ross SR, Graves RA,
Cinti S, Lafontan M, and Lowell BB. Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity. J.Biol.Chem. 275:
34797-34802, 2000.
10. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J,
Mootha V, Cortright R, Muoio DM, and Lowell BB. Energy metabolism in uncoupling protein 3 gene knockout mice. J.Biol.Chem. 275: 16258-16266, 2000.
11. Ziotopoulou M, Mantzoros CS, Hileman SM, & Flier JS. Differential expression of
hypothalamic neuropeptides in the early phase of diet-induced obesity in mice.
Am. J. Physiol. Endocrinol. Metab. 279:E383-E845, 2000.
12. Scrocchi LA & Drucker DJ. Effects of Aging and a High Fat Diet on Body Weight and
Glucose T olerance in Glucagon-Like Peptide-1 Receptor -/- Mice.
Endocrinology 139:3127- 3132, 1998.
13. Ghibaudi L, Cook J, Farley C, Van Heek M, & Hwa J.Fat Intake Affects Adiposity,
Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats.
Obes. Res. 10:956-963. 2002
14. Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS & Kalra SP. Central Leptin Gene
erapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemeia, and
Hyperinsulinemia. Diabetes 51:1729-1736, 2001.
15. Tang H, Vasselli JR, Wu EX, Boozer CN, & Gallagher D. High-Resolution Magnetic
Resonance Imaging T racks Changes in Organ and Tissue Mass in Obese and Aging Rats.
Am J Physiol (Regulatory Integrative Comp Physiol) 282:R890-R899, 2002.
16. Bowen H, Mitchell TD, & Harris RBS (Dept. of Foods and Nutr, U of Georgia).
Method of Leptin Dosing, Strain, and Group Housing Influence Leptin Sensitivity in High-Fet-Fed Weanling Mice. AJP-Regul Integr Comp Physiol 284:R87-R100, 2003. 17. Harris RBS, Mitchell TD, & Hebert S (Pennington Biomedical Research Center, Baton
Rouge, LA). Leptin-Induced Changes in Body Composition in High Fat-Fed Mice.
AJPRegul Integr Comp Physiol 284:R87-R100, 2003.
18. Anini, Y. and Brubaker, P. L. Role of Leptin in the Regulation of Glucagon-Like
Peptide-1 Secretion. Diabetes 52:252-259, 2003.
19. Bluher, S., Responsiveness to Peripherally Administered Melanocortins in Lean and
Obese Mice. Diabetes 53:82-90, 2004.
20. Brunengraber, D. Z., et al. Influence of diet on the modeling of adipose tissue
triglycerides during growth. Am J Physiol Endocrinol Metab 285: E917-E925, 2003. 21. Challis, B. G., et al. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding
but respond normally to the acute anorectic effects of peptide-YY3-36.
PNAS 101: 13: 4695- 4700, 2004.
22. Cohen, A. W., B. Razani, X. B. Wang, T. P. Combs, T. M. Williams, P. E. Scherer, and
M. P. Lisanti. Caveolin-1-deficient mice show insulin resistance and defective
insulin receptor protein expression in adipose tissue. Am J Physiol Cell Physiol 285: C222-C235, 2003.
23. Combs, T. P., et al. A T ransgenic Mouse with a Deletion in the Collagenous Domain of
Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin
Sensitivity. Endocrinology 145:367-383, 2004.
24. Conarello, S. L., et al. Mice lacking dipeptidyl peptidase IV are protected against obesity
and insulin resistance. PNAS, 100:11: 6825-6830, 2003.
25. Dhar, M. S., et al. Mice Heterozygous for Atp10c, a Putative Amphipath, Represent a
Novel Model of Obesity and Type 2 Diabetes. J. Nutr. 134: 799-805, 2004.
26. El-Haschimi, K., S. D. Dufresne, M. F. Hirshman, J. S. Flier, L. J. Goodyear, and C.
Bjørbæk. Insulin Resistance and Lipodystrophy in Mice Lacking Ribosomal S6 Kinase 2.
Diabetes 52:1340-1346, 2003.
27. Felipe, F., M. L. Bonet, J. Ribot, and A. Palou. Modulation of Resistin Expression by
Retinoic Acid and Vitamin A Status. Diabetes 53:882-889, 2004.
28. Felipe, F., M.L. Bonet, J. Ribot and A. Palou. Up-regulation of muscle uncoupling
protein 3 gene expression in mice following high fat diet, dietary vitamin A
supplementation and acute retinoic acid-treatment. International Journal of Obesity
27: 60-69, 2003.
29. Fu, J., et al. Oleylethanolamide regulates feeding and body weight through activation
of the nuclear receptor PPAR. Nature 425:90-93, 2003.
30. Gavrilova, O., et al. Liver Peroxisome Proliferator-activated Receptor Contributes to
Hepatic Steatosis, T riglyceride Clearance, and Regulation of Body Fat Mass.
e Journal o
f Biological Chemistry 278:36:34268-34276, 2003.
31. Haluzík, M., O. Gavrilova and D. LeRoith. Peroxisome Proliferator-Activated
Receptor- Deficiency Does Not Alter Insulin Sensitivity in Mice Maintained on
Regular or High-Fat Diet: Hyperinsulinemic-Euglycemic Clamp Studies.
Endocrinology 145:1662-1667, 2004.32. Hancock, A.A. et al. Antiobesity effects of A-331440, a novel non-imidazole histamine
H3 receptor antagonist. European Journal of Pharmacology 487:183-197, 2004.
33. Hennige, A. M., et al. Upregulation of insulin receptor substrate-2 in pancreatic b cells
prevents diabetes. J. Clin. Invest. 112:1521-1532, 2003.34.
34. Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Validation of a high-resolution
X-ray computed tomography system to measure murine adipose tissue depot mass in situ and longitudinally. Journal of Pharmacological and T oxicological Methods
47: 99- 106, 2002.
35. Hileman, S. M., D.D. Pierroz, H. Masuzaki, C. Bjørbæk, K. El-Haschimi, W. A. Banks,
and J. S. Flier. Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity.
Endocrinology 143:775-783, 2002.
36. Ishii, M., H. Fei, and J. M. Friedman. Targeted disruption of GPR7, the endogenous
receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.
PNAS 100:18:10540-10545, 2003.
37. Joseph, J. W., V. Koshkin, C-Y Zhang, J. Wang, B. B. Lowell, C. B. Chan, and M.B.
Wheeler. Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory
Capacity After a High-Fat Diet. Diabetes 51:3211-3219, 2002.
38. Kim, S., et al. Effects of High-Fat, Angiotensinogen (agt) Gene Inactivation, and
Targeted Expression to Adipose Tissue on Lipid Metabolism and Renal Gene Expression.
Horm Metab Res 34:721-725, 2002.
39. Kumar, M. V., T. Shimokawa, T. R. Nagy, and M. D. Lane. Differential effects of a
centrally acting fatty acid synthase inhibitor in lean and obese mice.
PNAS 99:4: 1921-1925, 2002.
40. Lambert, P. D., et al. Ciliary neurotrophic factor activates leptin-like pathways and
reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant
obesity. PNAS 98:8: 4652-4657, 2001.
41. Le Laya, S., et al. Decreased Resistin Expression in Mice with Different Sensitivities to a
High-Fat Diet. Biochemical and Biophysical Research Communications
289:2:564-567, 2001.
42. Li, J., K. Takaishi, W. Cook, S. K. McCorkle, and R. H. Unger. Insig-1 ''brakes''
lipogenesis in adipocytes and inhibits differentiation of preadipocytes.
PNAS 100:16:9476-9481, 2003.
43. Ludwig, D. S., et al. Melanin-concentrating hormone overexpression in transgenic mice
leads to obesity and insulin resistance. J. Clin. Invest. 107:379-386, 2001.
44. Moon, Y. S., et al. Mice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth
Retardation and Accelerated Adiposity. Molecular And Cellular Biology
大气
稳定度分级
22:15: 5585-5592, 2002.
45. Murray, I., A. D. Sniderman, P. J. Havel, and K. Cianflonei. Acylation Stimulating
Protein (ASP) Deficiency Alters Postprandial and Adipose Tissue Metabolism in
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46. Phan,L. K., F. Lin, C. A. LeDuc, W. K. Chung, and R. L. Leibel. e mouse
mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.
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47. Pierroz, D. D., M. Ziotopoulou, L. Ungsunan, S. Moschos, J. S. Flier, and C. S.
Mantzoros. Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity. Diabetes 51:1337-1345, 2002.
48. Rosenfeld, C. S., K. M. Grimm, K. A. Livingston, A. M. Brokman, W. E. Lamberson,
and R. M. Roberts. Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate. PNAS 100:8:4628-4632, 2003. 49. Chirala, S. S., et al. Fatty acid synthesis is essential in embryonic development: Fatty acid
synthase null mutants and most of the heterozygotes die in utero.
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50. Takahashi, N., et al. Divergent Effects of Leptin in Mice Susceptible or Resistant to
Obesity. Horm Metab Res 34:691-697, 2002.
51. upari, J. N., L. E. Landree, G. V. Ronnett, and F. P. Kuhajda. C75 increases peripheral
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52. T ortoriello, D. V., J. Mcminn, and S. C. Chua. Dietary-Induced Obesity and
Hypothalamic Infertility in Female DBA/2J Mice.
财务危机>小样本
Endocrinology 145: 1238-1247, 2004.
53. Weisberg, S. P., et al. Obesity is associated with macrophage accumulation in adipose
tissue. J. Clin. Invest. 112:1796-1808, 2003.
54. Xu, H. et al. Chronic inflammation in fat plays a crucial role in the development of
obesity related insulin resistance. J. Clin. Invest. 112:1821-1830, 2003.
55. Yamashita, T., et al. Enhanced insulin sensitivity in mice lacking ganglioside GM3.
PNAS 100:6:3445-3449, 2003.
56. Bagnasco, M., M. G. Dube, A. Katz, P. S. Kalra, and S. P. Kalra. Leptin Expression In
Hypothalamic Pvn Reverses Dietary Obesity And Hyperinsulinemia But Stimulates
Ghrelin. Obes Res. 11:1463-1470, 2003.
57. Borowsky, B., et al. Antidepressant, anxiolytic and anorectic effects of a
melaninconcentrating hormone-1 receptor antagonist.
Nature Medicine 8:8:825-830, 2002.
58. Chan, C. B., et al. Increased Uncoupling Protein-2 Levels in b-cells Are Associated
With Impaired Glucose-Stimulated Insulin Secretion. Diabetes 50:1302-1310, 2001. 59. Chen, L. and B. L. G. Nyomba. Glucose Intolerance and Resistin Expression in Rat
Offspring Exposed to Ethanol in Utero: Modulation by Postnatal High-Fat Diet.
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60. Farley, C., J. A. Cook, B. D. Spar, T. M. Austin, and T. J. Kowalski. Meal Pattern
Analysis Of Diet-Induced Obesity In Susceptible And Resistant Rats.
Obes Res. 11:845-851, 2003.
61. Gao, J., L. Ghibaudi, M. Van Heek, J. J. Hwa. Characterization of diet-induced obese
rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet. Brain Research 936:87-90, 2002.
62. Ogilvie, K. M., R. Saladin, T. R. Nagy, M. S. Urcan, R. A. Heyman, and M. D.
Leibowitz. Activation of the Retinoid X Receptor Suppresses Appetite in the Rat.
Endocrinology 145:565-573, 2004.
63. Shklyaev, S., et al. Sustained peripheral expression of transgene adiponectin offsets the
development of diet-induced obesity in rats. PNAS 100:24:14217-14222, 2003.
64. Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Antiobesity effects of chronic
现代教育科学cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice.
European Journal of Pharmacology 462:125-132, 2003.
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