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Process for the preparation of 2-alkyl cyclopent-2

专利名称：Process for the preparation of 2-alkyl cyclopent-2-enones

发明人：Enrico Dalcanale

申请号：US06/835246

申请日：19860303

公开号：US04673759A

公开日：

19870616

专利内容由知识产权出版社提供

摘要：A process for the preparation of 2-alkyl cyclopent-2-enones having the formula: ##STR1## wherein R is as defined hereinafter. An &agr; -olefin having the formula

CH.sub.2 ═CH--CH.sub.2 R is oxidized to the corresponding epoxide. The epoxide is reacted with an alkylating agent having the formula Na.sup.+ CH(COOR").sub.2 !.sup.-, wherein R" is an ethyl, an isopropyl, or an isobutyl radical. An &agr;-carbalkoxy-&ggr; -alkyl lactone is obtained, which, through saponification and decarboxylation, yields a

&ggr;-alkyl lactone having the formula: ##STR2## which is reacted with a protic acid, thereby obtaining, by cyclization, the desired 2-alkylcyclopent-2-enone. The obtained products are intermediates for the production of pharmaceutical products and of drugs for veterinary use, in particular prostaglandin.

申请人：MONTEDISON S.P.A.

代理机构：Stevens, Davis, Miller & Mosher

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