Asian Journal of Pharmaceutical Sciences14(2019)
521–530
Available online at
www.sciencedirect
journal homepage:www.elsevier/locate/AJPS
Original Research Paper
Exploring the relationship of hyaluronic acid
molecular weight and active targeting efficiency for designing hyaluronic acid-modified nanoparticles
Lu Zhong a,Yanying Liu a,Lu Xu a,Qingsong Li a,Dongyang Zhao a,
Zhenbao Li a,Huicong Zhang a,Haotian Zhang b,Qiming Kan b,Jin Sun a,∗,
Zhonggui He a,∗
a Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang110016,China
b School of Pharmacy,Shenyang Pharmaceutical University,Shenyang110016,China
人生这里
a r t i c l e i n f o
Article history:
Received30July2018
我形我速5
Revised12October2018
Accepted4November2018
Available online6December2018
Keywords:
Hyaluronic acid
Molecular weight
Active targeting efficiency
CD44receptor
微旋风Potential mechanism第一线集团
a b s t r a c t
Although it is reported that the targeting ability of hyaluronic acid(HA)-based nanoparticles
(NPs)is molecular weight(MW)dependent,the influence of HA MW on targeting efficiency
of HA-functionalized NPs and the underlying mechanism remain elusive.In this study,we
constituted three HA-functionalized Dox-loaded NPs(Dox/HCVs)different HA MWs(7,63,
and102kDa)and attempted to illustrate the effects of HA MW on the targeting efficiency.
武林风阳阳The three Dox/HCVs had similar physiochemical and pharmaceutical characteristics,but
showed different affinity to CD44receptor.Furthermore,Dox/HCV-63exerted the best tar-
geting effect and the highest cytotoxicity compared with Dox/HCV-7and Dox/HCV-102.It
was interesting to found that both the HA-CD44binding affinity and induced CD44cluster-
ing by HA-based NPs were HA MW-dependent,the two of which determine the apparent
targeting efficacy of Dox/HCV NPs in the conflicting directions.Those results laid a good
foundation for rationally designing HA-based NPs in cancer therapy.
©2018Shenyang Pharmaceutical University.Published by Elsevier B.V.
This is an open access article under the CC BY-NC-ND license.
(/licenses/by-nc-nd/4.0/) 1.Introduction
Comparing with conventional nontargeted nanoparticulate
drug delivery systems(Nano-DDS),active targeting Nano-DDS
has attracted great attention due to enhanced therapeutic
∗Corresponding authors.Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang110016,China.Tel.:+8624 23986321
E-mail addresses:sunjin@syphu.edu(J.Sun),hezhgui_student@aliyun(Z.He).
Peer review under responsibility of Shenyang Pharmaceutical University.
effect and reduced undesirable side effects.They are usu-
ally fabricated by modifying nanocarriers with active target-
ing moieties which recognize specific biomarkers on the sur-
face of tumor cells,such as antibody[1],nucleic acid[2],pep-
tide[3],hyaluronic acid[4],some essential nutrients related
香港历史/10.1016/j.ajps.2018.11.002 1818-0876/©2018Shenyang Pharmaceutical University.Published by Elsevier B.V.This is an open access article under the CC BY-NC-ND license.(/licenses/by-nc-nd/4.0/)
豫公网安备41160202000603
站长QQ:729038198
关于我们
投诉建议