Zhengming Chen, PhD, MPH, MS
LA 0008C, 402 67th Street, New York, NY 10065
Tel: 646-962-8015
Email: *******************.edu
Education
M.P.H. (2010)
Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612
Ph.D. (1999)
Molecular Biology, Department of Biology, Xiamen University, Xiamen, Fujian 361005
M.S. (1996)
Microbiology, Department of Biology, Xiamen University, Xiamen, Fujian 361005
B.S. (1991)
Cell Biology, Department of Biology, Xiamen University, Xiamen, Fujian 361005
Professional Experience
Nov. 2011 – present Research Biostatistician, Division of Biostatistics and Epidemiology,
Department of Public Health, Weill Cornell Medical College, New
York, NY, USA
July 2010 – Nov. 2011 Research Assistant Professor, School of Medicine, Karmanos
Cancer Institute, Wayne State University, Detroit, MI, USA Nov. 2007 – July 2010 Research Associate, H. Lee Moffitt Cancer Center and Research
Institute, Tampa, FL, USA
Apr. 2003 – Nov. 2007 Post-doc Fellow, H. Lee Moffitt Cancer Center and Research
Institute, Tampa, FL, USA
Aug. 1999 – Apr. 2003 Senior Research Fellow, Institute of Molecular and Cell Biology,
National University of Singapore, Singapore
July 1991 – July 1993 Instructor, Yichun Normal College, Yichun, Jiangxi Province,
P.R.China
Professional Membership
American Statistical Association (ASA)
American Association for Cancer Research (AACR)
Professional Certificates
Certified SAS9 programmer;
Certified in Public Health (CPH);
Activities
Jan., 2014 – present Member of Clinical Research Evaluation Committee (CSEC) at Weill
Cornell Medical College
Sept., 2013 – present Co-director of Biostatistics Core for PO1 (PI: Selina Chen-Kiang)
application
Oct., 2013 – present Primary biostatistician of Biostatistics Core for SPORE (PI: Mark Rubin)
application
Sept., 2014 – present Primary biostatistician of Bioinformatics and Biostatistics Core for
居家新
主张lymphoma PO1 application
May, 2012 Organized and gave a presentation to the biostatisticians within the教材插图 department. Title: SAS macro and dynamic reporting Dec., 2011 – May 2014 Primary statistical reviewer for the journal The Laryngoscope
Training
2012 NHGRI Short Course on Next Generation Sequencing: Technology and Statistical Methods, University of Alabama at Birmingham;
Patent
Treatment of restenosis and stenosis with Dasatinib (Patent No.: US 8,815,260 B1) Selected Publication
费大为
•Park K, Chen Z, MacDonald TY, Siddiqui J, Ye H, Erbersdobler A, Shevchuk M, Robinson BD, Beltran H, Rubin MA, Mosquera JM. Prostate Cancer with Paneth Cell-Like Neuroendocrine Differentiation Harbors AURKA Gene Amplification. Hum Pathol. 2014; Jun 26. PMID: 25128228
•Khani F, Mosquera JM, Park K, Blattner M, O'Reilly C, MacDonald TY, Chen Z, Srivastava A, Tewari AK, Barbieri CE, Rubin MA, Robinson BD. Evidence for Molecular Differences in半月刊
Prostate Cancer Between African American and Caucasian Men. Clin Cancer Res. 2014; Jul 23. PMID: 25056375
•Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J,
Gygi SP, Kaelin WG Jr, Zhang Q. Prolyl hydroxylation by EgIN2 destabilizes FOXO3a by blocking its interaction with the USP98x deubiquitinase. Genes Dev. 2014; 28(13):1429-44. PMID: 24990963
•D’Alfonso TM, Hannah J, Chen Z, Liu Y, Zhou P, Shin SJ. Axl receptor tyrosine kinase expression in breast cancer. J Clin Pathol. 2014; 28(13): 1429-44. PMID: 24904064 •Pollock A, Bian S, Zhang C, Chen Z, Sun T. Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathway. Cell Rep. 2014; 7(4): 1184-96. PMID: 24813889
•Nguyen MT, Stessin A, Nagar H, D’Alfonso TM, Chen Z, Cigler T, Hayes MK, Shin SJ. Impact of oncotype DX recurrence score in the management of breast cancer cases. Clin Breast Cancer. 2014; 14(3): 182-90. PMID: 24486121
•Zhang Y, Li X, Chen Z, Bepler G. Ubiquitination and degradation of ribonucleotide reductase M1 by the polycomb group proteins RNF2 and Bmi1 and cellular response to gemcitabine. PloS one. 2014; 9(3): e91186. PMID: 24614341
•Koslow SB, Eisenberg RE, Qiu Q, Chen Z, Swistel A, Shin SJ. Sentinel lymph node biopsy is a reliable method for lymph node evaluation in neoadjuvant chemotherapy treated breast cancer patients. Am Surg. 2014; 80(2): 171-7. PMID: 24480218
•Kawaguchi KR, Lu FI, Kaplan R, Liu YF, Chadwick P, Chen Z, Brogi E , Shin SJ. In search of the ideal immunopanel to distinguish metastatic mammary carcinoma from primary lung carcinoma; a tissue microarray study of 207 cases. Appl Immunohistochem Mol Morphol. 2014; 22(4): 266-74. PMID: 23958551
•Zhou J, Chen Z, Malysa A, Li X, Oliveira P, Zhang Y , Bepler G. A kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy. PLoS One. 2013; 8(3):e58091. PMID: 23483975
•Zhang Y, Shin SJ, Liu D, Ivanova E, Foerster f, Ying H, Zheng H, Xiao Y, Chen Z, Protopopov A, DePinho R , Paik JH. ZNF365 promotes stability of fragile sites and telomeres. Cancer Discovery. 2013;3(7):798-811. PMID: 23776040
•Zhou J, Roh JW, Bandyopadhyay S, Chen Z, Munkarah AR, Hussein, Alosh B, Jazaerly T, Hayek K, Semaan A, Sood AK, Ali-Fehmi R. Overexpressin of enhancer of zeste homolog 2 (EZH2) and focal adhesion kinase (FAK) in high grade endometrial carcinoma. Gynecol Oncol. 2013; 128(2): 344-8. PMID: 22871469
•D'Alfonso TM, Liu YF, Chen Z, Chen YB, Cimino-Mathews A, Shin SJ. SP3, a reliable alternative to
维奇网Hercep Test in determining HER-2/neu status in breast cancer patients. J Clin Pathol. 2013; 66(5):409-14. PMID: 23386665
•Chen Z , Zhou J, Zhang Y & Bepler G, Modulation of the Ribonucleotide Reductase M1 –Gemcitabine Interaction in vivo by N-ethylmaleimide. Biochem Biophys Res Commun. 2011; 413(2): 383-
•Ren Y, Chen Z, Chen L & Wu J, Critical role of Shp2 in tumor growth involving regulation of c-Myc. Genes & Cancer. 2010; 1(10):994-
•Zhou J, Oliveira P, Li X, Chen Z & Bepler G, Modulation of the Ribonucleotide Reductase-antimetabolite drug interaction in cancer cell lines. Journal of Nucleic Acids.2010; 28;2010:597098
•Pagan B, Isidro A, Coppola D, Chen Z, Ren Y, Wu J & Appleyard C, Effect of a Neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer. Anticancer Research. 2010; 30(9):3345-
•Ren Y, Chen Z, Chen L, Woods NT, Reuther GW, Cheng JQ, Wang HG & Wu J. Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL. J Biol Chem. 2007; 282(50):36463 -
•Wong CK*, Chen Z*, So KL, Li D & Li P. Polycomb group protein RING1B is a direct substrate of Caspases-3 & -9. Biochim Biophys Acta. 2007; 1773(6):844- * co-first authors.
•Chen Z, Lee FY, Bhalla KN & Wu J. Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib). Mol Pharmacol. 2006; 69(5):1527-, featured article
•Meng S*, Chen Z* & Wu J. Participation of both Gab1 & Gab2 in the activation of the Erk mitogen activated protein kinase pathway by epidermal growth factor. Biochem J. 2005; 391(Pt 1):143- * co-first authors
•Zhou Z, Toh SY, Chen Z, Guo K, Ng CP, Ponniah S, Lin S, Hong W & Li P. Cidea-deficient mice have lean phenotype & are resistant to obesity. Nat Genet. 2003; 35(1): 49-
•Chen Z, Guo K, Toh SY, Zhou Z & Li P. Mitochondria localization & Dimerization are required for CIDE-B to induce apoptosis. J. Bio. Chem. 2000; 275: 22619-
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