口腔用胶原蛋白基质用于后牙区位点保存的实验研究

口腔颌面外科杂志2018年10月第28卷第5期

Journal of Oral and Maxillofacial Surgery Vol.28No.5October,2018

・251・

罗迪克发球口腔用胶原蛋白基质用于后牙区位点保存的实验研究

沈阳音乐学院南校区地址金福荣，王伟伟，廖建兴

(上海牙组织修复与再生工程技术，同济大学口腔医学院•同济大学附属口腔医院口腔颌面外科，上海200072)［摘要］目的：通过动物实验探究骨替代材料促进后牙区拔牙位点保存的效果，为临床后牙区位点保存和早期干预提供参考%方法：选取1岁龄健康雌性Beagle犬3只，全麻下拔除下颌双侧第2、3、4前磨牙及第1磨牙，共24个拔牙位点％随机分为3组:G1组不做处理；G2组放置口腔用胶原蛋白基质；G3组放置Bio-Oss骨粉，每组各包含1个不同的拔牙位点%所有犬拔牙3个月后同期处死取下颌骨制备标本，行Micro-CT扫描、硬组织、7G染后组织形态学观察%结果:Micro-CT分析结果显示G2组和G3组中骨(BV/TV)&骨小梁厚度!Tb.Th)均高于G1组，差异具有统计学意义(!<0.05)；G3组骨小梁数目(Tb.N)高于G1组，学意义(!<0.05)；3组间骨小梁(Tb.Sp)学；G2和G3组中各参学意义％VG染结果G2组和G3组中骨胶原纤G1组致密%结论：口腔用胶原蛋白基质可尝试作为位点保存的骨替代材料使用%

［关键词］位点保存；拔牙；骨替代材料

对时网［中图分类号］R782.4［文献标志码］A［文章编号］1005-4979(2011)05-0251-05

长春大学学报

doi：10.3969/j.issn.l005-4979.2011.05.004

An Experimental Study Site Preservation in Posterior Region of the Mandible in the Dog

JIN Fu-rong+WANG Wei-wei+LIAO Jian-xing

(Department of Oral and Maxillofacial Surgery^School and HospitalStomatology,

Tongji University,Shanghai Engineering Research Center of Tooth Restoration

and Regeneration,Shanghai200072+China)

［Abstract］Objective：To explore the effect of collagen matrix,a bone substitute material on the repair of alveolar bone in the posterior region.Methods：The second,third,and fourth mandibular premolars and the first mandibular molars of three1-year-old female beagle dogs were removed under general anesthesia.A total of24extraction sites were randomly selected and treated differently

as follows.Group1(G1)was control group.Group2(G2)was filled with oral collagen matrix.Group3(G3)was filled with Bio-Oss.After3months of tooth extraction,animals were sacrificed and the mandible specimen were harvested for histologic and morphological studies.Results：Micro-CT scan showed the bone volume fraction(BV/TV)and trabecular thickness(Tb.Th)were higher in G2and G3than those in G1(!<0.05).The trabecular number(Tb.N)was higher in G3than in G1(!<0.05).The differences were statistically significant.There was no significant differences in trabecular space(Tb.Sp)among the three groups.There were no statistically significant differences of parameters in G2and G3groups.VG staining showed that the collagen fibers in G2and G3groups were denser than those in G1.Conclusion：The oral collagen matrix may promote site preservation in extraction wounds,as to translate into clinical use,further studies are needed.

惊弓之鸟教学实录

［Keywords］site preservation;tooth extraction;bone substitute；collagen matrix

因外伤、炎症、肿瘤等原因导致牙缺失后，常伴随牙槽骨的过和性，牙骨

收稿日期：2018-08-27修回日期：2018-09-29

作者简介：金福荣（1991—），男，回族，硕士研究生.E-mail: yase@tongji.edu天津中医学院第一附属医院

通信作者：廖建兴，教授.E-mail:ljx@tongji.edu 骨量不足，的使用。有学者研究，牙拔除后，牙的后的1年25%,50%左右的牙槽骨叫后牙区骨的，上颌i 提升术、、自骨移提修复率叫

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