蛋白酶切位点

细胞自噬

Enzymes	E.C. Number	Cleavage sites
Serine proteases	E.C.3.4.21.
α-chymotrypsin(胰凝乳蛋白酶，糜蛋白酶)	E.C.3.4.21.1	Tyr-\|-Xaa, Trp-\|-Xaa, Phe-\|-Xaa, and also Leu-\|-Xaa, Met-\|-Xaa,
Trypsin (胰朊酶，胰蛋白酶)	E.C.3.4.21.4	Arg-\|-Xaa, Lys-\|-Xaa,
Pancreatic elastase(胰弹性蛋白酶)	E.C.3.4.21.36	Ala-\|-Xaa,and also Gly-\|-Xaa, Val-\|-Xaa, Ser-\|-Xaa,
Thrombin(凝血酶)	E.C.3.4.21.5二硫化碳毒性	Arg-\|-Gly,
Plasmin(胞质素，胞浆素)	E.C.3.4.21.7	Lys-\|-Xaa,> Arg-\|-Xaa
Prolyl oligopeptidase,or prolyl endopeptidase	E.C.3.4.21.26	Pro-\|-Xaa,>> Ala-\|-Xaa
Plasma kallikrein(血浆激肽释放酶)	E.C.3.4.21.34 桓仁东山中学	Arg-\|-Xaa, Lys-\|-Xaa,including Arg-\|-Ser, Lys-\|-Arg,
Leukocyte elastase(白细胞弹性蛋白酶 ),or neutrophil elastase(中性白细胞弹性蛋白酶),or lysosomal elastase(溶酶体弹性蛋白酶)	E.C.3.4.21.37	Val-\|-Xaa, Ala-\|-Xaa,
Cysteine proteases	E.C.3.4.22.
Cathepsin B(组织蛋白酶)	E.C.3.4.22.1	Arg-Arg-\|-Xaa, and also Leu-\|-Xaa, Ala-\|-Xaa, Phe-\|-Xaa, Trp-\|-Xaa,
测绘与空间地理信息Clostripain(梭菌蛋白酶),or endoproteinase Arg-C	E.C.3.4.22.8	Arg-\|-Xaa including Arg-\|-Pro,but not Lys-\|-Xaa
Calpain(钙激活中性蛋白酶)-1,or μ-calpain	E.C.3.4.22.52	Met-\|-Xaa, Tyr-\|-Xaa and Arg-\|-Xaa(with Leu or Val as the P2 residue)
Aspartic acid proteases	E.C.3.4.23.
Pepsin(胃朊酶，胃蛋白酶)	E.C.3.4.23.1	Preferentially Phe-\|-Xaa, Tyr-\|-Xaa, and also Leu-\|-Xaa,and Trp-\|-Xaa,,ideally with Xaa= Phe,Trp,or Tyr
Cathepsin(组织蛋白酶)D	E.C.3.4.23.5	Preferentially Phe-\|-Xaa, Tyr-\|-Xaa, and also Leu-\|-Xaa, ideally with Xaa ≠ Ala or Val
Metalloproteases	E.C.3.4.24.
Neprilysin(脑啡肽酶),or enkephalinase(脑啡肽酶),or neutral endopeptidase	E.C.3.4.24.11	Xaa-\|-Tyr, Xaa-\|-Phe, Xaa-\|-Trp, and Xaa-\|-Leu,
Thimet oligopeptidase(甲拌磷寡肽酶),or endo-oligopeptidase A,or endopeptidase(肽链内切酶)24.15,or pz-peptidease(肠促胰酶素)	E.C.3.4.24.15	Xaa-\|-Arg, Xaa-\|-Ser, Xaa-\|-Ile, Xaa-\|-Ala, Xaa-\|-Gly,
Aminopeptidases	E.C.3.4.11.	N-term
Leucyl-aminopeptidase	E.C.3.4.11.1	Preferentially Leu-\|-Xaa,but not Arg-\|-Xaa,and Lys-\|-Xaa,
Aminopeptidase M or N,or alanyl- aminopeptidase,or membrane alanine aminopeptidase	E.C.3.4.11.2	Preferentially Ala-\|-Xaa,and Tyr-\|-Xaa,if Yaa-Pro-\|-Xaa in term with Yaa = Ala,Val,Leu,Ile,Phe,Tyr or Trp,then the dipeptide Yaa-Pro could be released
Aminopeptidase B	E.C.3.4.11.6	Arg-\|-Xaa, Lys-\|-Xaa,
Aminopeptidase A,or angiotensinase,or glutamyl-aminopeptidase	E.C.3.4.11.7	Glu-\|-Xaa>> Asp-\|-Xaa,
Dipeptidyl-peptidases and tripeptidyl-peptidases	E.C.3.4.14.	N-term(di-and tripeptides)
Dipeptidyl-peptidase I,or cathepsin(组织蛋白酶) C or J	E.C.3.4.14.1	Xaa-Yaa-\|-Zaa,if Xaa ≠ Arg or Lys,or Yaa ≠ Pro,or Zaa ≠ Pro
Dipeptidyl-peptidase IV	E.C.3.4.14.5	Preferentially Xaa-Pro-\|-Zaa,(but also Xaa-Ala-\|-Yaa) with Yaa ≠ Pro or Hyp
Prolyl tripeptyl-peptidase	E.C.3.4.14.12	Xaa-Yaa-Pro-\|-Zaa,if Zaa ≠ Pro
Peptidyl-Dipeptidases	齐齐哈尔铁路工程学校E.C.3.4.15.	swi.tC-term
Peptidyl-depeptidase A, or angiotensin-converting enzyme	E.C.3.4.15.1	Xaa-\|-Yaa-Zaa,if Yaa ≠ Pro or Zaa ≠ Asp or Glu
Metallo-carboxypeptidases	E.C.3.4.17.	C-term
Carboxypeptidase A	E.C.3.4.17.1	Xaa-\|-Yaa if Yaa ≠ Asp,Glu,Arg,Lys or Pro
Carboxypeptidase B,or protaminase	E.C.3.4.17.2	Xaa-\|-Arg and Xaa-\|-Lys
Carboxypeptidase N,or Lysine(arginine), Carboxypeptidase(羧基肽酶),or kininase I(激肽酶)	E.C.3.4.17.3	Xaa-\|-Lys>> Xaa-\|-Arg
Carboxypeptidase U or R	E.C.3.4.17.20	Xaa-\|-Arg and Xaa-\|-Lys
Glutamate Carboxypeptidase II,or folate hydrolase	E.C.3.4.17.21	Xaa-\|-Glu,preferentially with Xaa= Asp or Glu

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