AMPA receptor trafficking and Synaptic plasticity
require SQSTM1/p62
期刊名称： Hippocampus胡银波
作者： Jianxiong Jiang,Kodeeswaran Parameshwaran,M Lamar
横山大刀队
Seibenhener,Myoung-Goo Kang,Marie W Wooten
年份： 2009年
期号： 第4期
日本现人类头盖骨关键词： GluR1; aPKC; LTP; phosphorylation; surface delivery混沌模式
涡轮泵
摘要：SQSTM1/p62 is a multidomain/scaffold for the atypical protein kinase Cs (aPKC). Phosphorylation of AMPA receptors by PKC has been shown to regulate their insertion in the postsynaptic membrane. Here, we directly tested whether p62 could interact with AMPA receptor subun
人造神
its and influence their trafficking and phosphorylation. GluR1 receptor intracellular loop L2-3 and the ZZ-type zinc finger domain of p62 are essential for the interaction between these two proteins. In this context, both p62 and aPKC-mediated phosphorylation were necessary for surface delivery of the receptor. Our findings reveal that p62 is the first protein identified that interacts with a region of the GluR receptor other than the C-terminal tail. Furthermore, mice deficient in p62 displayed impaired hippocampal CA1 long-term potentiation (LTP), along
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