分子量380.35溶解性(25°C )
肝微粒体酶
DMSO 分子式C H N O Water CAS 号368449-04-1Ethanol
储存条件
3年 -20°C 粉末状
生物活性
鸭子捉兔
MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse
transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.
国家形象宣传片人物篇
不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA 指南) 小鼠
大鼠兔豚鼠仓鼠狗重量 (kg)0.020.15 1.80.40.0810体表面积 (m )0.0070.0250.150.050.020.5K 系数 3
爆炸和火灾危险环境电力装置设计规范6
12解放日报改版
8
5
20
动物 A (mg/kg) = 动物 B (mg/kg) ×
动物 B 的K 系数动物 A 的K 系数
例如,依据体表面积折算法,将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量,需要将22.4 mg/kg 乘以小鼠的K 系数(3),再除以大鼠的K 系数(6),得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg 。 齐奥赛斯库MST-312 目录号M7925
化学数据
2016262m m m m m