专利名称：Mst1 modulation of apoptosis in cardiac tissue and modulators of Mst1 for丽水市最新人事任免
板弹簧treatment and prevention of cardiac disease 发明人：Stephen F. Vatner,Junichi Sadoshima
海城黑社会申请号：US10683576
永远的林青霞申请日：20031010
公开号：US07160859B2护士应具备的素质
公开日：
20070109
摘要：The present invention relates to methods and agents for treatment, amelioration and prevention of cardiac disease, including cardiac myopathy, chronic heart failure and for management and reduction of cardiac myocyte death which may occur in response to ischemia/reperfusion or following myocardial infarction or other injury to the heart. The invention relates to methods for screening cardiotherapeutic compounds, including compounds which modulate cardiac myocyte apoptosis, particularly targeting Mst1 and the Mst1 pathway. The present invention further encompasses compounds identified by such screening methods and compositions comprising these compounds. The invention also provides methods for treatment, amelioration and prevention of cardiac disease comprising administering compounds or agents which modulate, particularly inhibit, Mst1 or the Mst1 kinase pathway, including administering a nucleic acid encoding an altered form of Mst1, particularly a dominant negative Mst1, which acts as an antagonist of Mst1.
申请人：Stephen F. Vatner,Junichi Sadoshima
地址：New York NY US,Berkeley Heights NJ US
国籍：US,US
施工设计一体化
代理机构：Klauber & Jackson, LLC.
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