2020, 35(4) ykxb.amegroups 271眼科学报
Yan Ke Xue Bao 视网膜母细胞瘤诊疗的研究进展 莫言 枯河林壮玲 综述 张平 审校
(中山大学中山眼科中心病理科,广州 510060)
[摘 要] 视网膜母细胞瘤(retinoblastoma ,RB)是婴幼儿最常见的眼内恶性肿瘤,严重危害患儿的生命及视
拉瓦锡之死
功能,对其早期诊断和精准是相关学者共同追求的目标。本文就目前RB 诊断和的研究进展进行综述。基因检测技术的进步有助于RB 的早期和精准诊断,同时RB 的方式也一直朝着提
高保眼率和减少并发症的方向发展。
[关键词] 视网膜母细胞瘤;诊断;
Research progress on the diagnosis and treatment of
retinoblastoma
LIN Zhuangling, ZHANG Ping
红外光通信装置(Department of Pathology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China)
Abstract Retinoblastoma (RB) is the most common intraocular malignant tumor in infants and young children, which
定滑轮和动滑轮seriously endangers their life and visual function. Early diagnosis and precise treatment are the common goals
pursued by related scholars. This article reviews the current research progress in RB diagnosis and treatment. The
progress of genetic testing technologies is conducive to the early and accurate diagnosis of RB, and its treatment
中档轿车
has been developing in the direction of higher eye-protective rate and fewer complications.
Keywords retinoblastoma; diagnosis; treatment
收稿日期(Date of reception):2020–07–23
通信作者(Corresponding author):张平,Email:**************doi: 10.3978/j.issn.1000-4432.2020.10.08
View this article at: /10.3978/j.issn.1000-4432.2020.10.08
视网膜母细胞瘤(r e t i n o b l a s t o m a ,R B)是婴幼儿最常见的眼内恶性肿瘤,占儿童恶性肿瘤的2%~4%,其发病率在全球范围内约为 1/20 000~1/15 000[1-2],相当于全球每年新增患者
约9 000例,其中我国每年新增患者约1 100例[3-4]。
大侦探西门约95%的病例发生于5岁前,其中约2/3发生于2岁
前。单眼R B 约占75%,发病年龄在2~3岁;双眼RB 多在2岁前发病[1-2,5]。RB 的发病没有种族和性
别倾向[6]。本文就RB 的诊疗方法及其研究进展综
述如下。1 诊断传统的RB 诊断主要依靠询问病史、眼底检查