槲皮素对糖尿病性周围神经病变的实验研究作者：王宝江 张家英 李 丹 崔 丽来源：《中国医药导报》2008年第14毛陈冰期 [摘要] 目的：验证醛糖还原酶抑制剂槲皮素对糖尿病性周围神经病变的作用。方法：Wistar大鼠180只（雌雄各半），首先随机取160只大鼠，采用四氧嘧啶腹腔注射建立糖尿病大鼠模型，测定模型组大鼠血糖及神经传导速度、痛觉潜伏期，余20迈克尔 卡特-威廉姆斯只健康大鼠作为正常对照组。将模型组随机分成8组，第8组作为模型对照组，第1～6组分别喂服不同剂量槲皮素，第7组喂服阳物。灌服50 d后测定各组痛觉潜伏期及神经传导速度。结果：第5、6模型组与模型对照组给药前后在神经传导速度方面比较，有非常显著性差异（P [关键词] 槲皮素；糖尿病；糖尿病性周围神经病变
[中图分类号] R969 [文献标识码]B [文章编号]1673-7210广东省机械设备成套局（2008）05（b）-018-03
石榴 郭沫若 The therapeutic action of quercetin on the painful diabetic peripheral neuropathy
WANG Bao-jiang1, ZHANG Jia-ying1, LI Dan1, CUI Li2朝阳新增病例基因序列公布>安瓦尔事件
(1.Department of Pharmacy, Fengtian Hospital Affiliated to Shenyang Medical College, Shenyang 110024, China;2. Department of Neurology, Fengtian Hospital Affiliated to Shenyang Medical College,Shenyang 110024, China)
[Abstract] Objective:To verify the therapeutic action of the aloes reduction enzyme inhibitor quercetin on the painful diabetic peripheral neuropathy caused by alloxan.Methods:180 Wistar rats were randomly divided into diabetic group and controlled group.160 rats comprise of the diabetic group,of which the glucose level , nerve conducting rate（NCR）and pain latent period（PLP）were measured. The left 20 rats were taken as the controlled group.The diabetic group was again randomly divided into 8 groups. Groups 1 to 6 were given quercetin of different dose respectively. Group 7 was treated with positive drugs, and group 8 was left as diabetic controlled group. The PLP and NCR of all groups were measured on the 50th day after administration. Results: Compared with the diabetic controlled group after administration，group 5 and group 6 showed significant difference in PLP and NCR(P
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