AcCOA：乙酰辅酶A；CIT：柠檬酸；DHAP：磷酸二羟丙酮；E4P：4-磷
酸赤藓糖；F6P：6-磷酸果糖；F1,6P：1,6-二磷酸果糖；FUM：延胡索酸；高斯函数
养殖技术顾问GA3P：3-磷酸甘油醛；G3P：3-磷酸甘油；G6P：6-磷酸葡萄糖；G6PA：6-
德国人的性格
磷酸葡萄糖酸；α-KG：α–酮戊二酸；LAC：乳酸；MAL：苹果酸；OAA：
草酰乙酸；PEP：磷酸烯醇式丙酮酸；3PG：3-磷酸甘油酸；PYR：丙酮
酸；Ru5P：5-磷酸核酮糖；R5P：5-磷酸核桃；SUC：琥珀酸；SUCCoA：
琥珀酰辅酶A；X5P：5-磷酸木酮糖.
胞内的代谢反应方程乐果q7
rl GLU+ATP→G6P+ADP
r2 G6P→F6P
r3 F6P+ATP→DHAP+G3AP+ADP
r4 DHAP+NADH→G3P+NAD
r5 G3P+ADP→GLY+ATP
r6 GA3P+NAD+ADP→ 3PG+NADH+ATP
r7 3PG→PEP
r8 PEP+ADP→PYR+ATP
三羧酸循环 Tricarboxylic acid cycle 路亚中国
r11 PYR+CoA+NAD→AcCoA+NADH+CO2
北京市人口与计划生育条例修正案r12 PYR+ATP+CO2→OAA+ADP
r14 OAA+AcCoA→ICI+CoA
r15 ICI+NAD→α-KG+NADH+CO2
r16 α-KG+CoA+NAD→SucCoA+NADH+CO2
r17 SucCoA+ADP+Pi→SUC+ATP+CoA
r18 SUC+FAD→FUM+FADH2
r19 FUM→MAL
r20 MAL+NAD→OAA+NADH
磷酸戊糖途径 Plentose phosphate pathway
r21 G6P+NADP→G6PA+NADPH
r22 G6PA+NADP→Ru5P+NADPH+CO2
r23 Ru5P→0.67X5P
r24 Ru5P→0.33R5P
r25 X5P+R5P→F6P+E4P
r26 X5P+E4P→F6P+GA3P
副产物形成 By-products synthesis r9 PYR+NADH→Lactate+NAD
r10 PYR+NADH→Ethanol+CO2+NAD
r13 PYR→PyrExt
氧化磷酸化 Oxidative phosphorylation
NADH+0.5O2+(P/O)ADP→NAD+(P/O)ATP
FADH2+0.5O2+0.5(P/O)ADP→0.5(P/O)ATP+FAD
用于维持的ATP消耗 ATP consumption for maintenance
ATP→ADP+Pi
生物量形成 Biomass formation
0.067G6P+0.064R5P+0.009GA3P+0.065PG+0.050PEP+0.176P
yr+0.095OAA+0.102KG+0.249AcCoA+1.142NADPH+0.157NA
D+3.82ATP→Biomass+1.142NADP+0.157NADH+0.127CO
2+3.8-2ADP
图4 补料发酵过程中胞浆3-磷酸甘油脱氢酶、6-磷酸葡萄糖脱氢酶、丙酮酸激酶酶活的时序变化Fig. 4 Time courses of the activity of ctGPD, G6PDH and PYK in fed-batch culturectGPD：胞浆3-磷酸甘油脱氢酶；G6PDH：6-磷酸葡萄糖脱氢酶；PYK：丙酮酸激酶 ctGPD: cytoplasmic glycerol 3-phosphate dehydrogenase; G6PDH: glucose-6-phosphate dehydrogenase; PYK: pyruvate kinase
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