Susceptibility of the bovine lens 115kDa beaded filament protein to degradation by calcium and厉剑
阿片受体激动剂calpain
期刊名称： Current Eye Research
学习兴趣与学习
习惯的培养
作者： Marcantonio,Julia M. 年份： 1992年
期号： 第1期
课题结题报告格式关键词： ALPHA-L-IDURONIDASE DEFICIENCY;SCHEIES SYNDROME;MPS I-
污水综合排放标准S;SYSTEMIC MUCOPOLYSACCHARIDOSIS;CORNEAL
CLOUDING;ULTRASTRUCTURAL ANALYSIS
摘要：The 115kDa cytoskeletal beaded filament protein of bovine lens fibres is degraded during opacifi
cation induced by increased internal calcium. The monoclonal antibody R2D2 to this protein has been used in whole lenses and native homogenates to follow the process of degradation and the production of break-down products. In the opaque outer cortex of whole bovine lenses with an internal Ca2+ of 2.0mM, both the 115kDa parent protein and the main degradation product (57kDa) were reduced in amount by almost 60%. No additional products were detected by the antibody. When native homogenates were incubated overnight with 10mM Ca2+ the protein could no longer be detected in SDS gels, but faintly reactive bands were detected by the antibody. Since these changes were dependent on the presence of increased calcium they were compared
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