ZHONGGUO YIXUEZHUANGBEI 16118-week-old male SHRs were divided in SHR group and 20 age-matched male Wistar Kyoto rats (WKYs) were divided in WKY group. Both of them were fed with standard diet. The systolic blood pressure (SBP) and heart rate were detected by using noninvasive tail-cuff method in the 0 week and 12th week, respectively. The serum AGT and serum Ang II were detected by ELISA. And the lesion of ultra structure about cardiac muscle tissue were evaluated under light microscope and electron microscope. Results: The results of ELISA indicated that the serum AGT and serum Ang II of SHR group were significantly higher than that of WKY group at 0 week and 12th week (t AGT =27.94, t =27.29, t AngII =16.20, t =31.33; P <0.05), respectively. The concentrations of serum AGT and serum AngII of rats with myocardial lesions of SHR group at 12th week were statistically significantly higher than that of SHR group at 0 week (t =15.17, t =13.77, P <0.05), respectively. And the concentrations of serum AGT and serum Ang II increased with the increase of the seriousness of myocardial lesions. Conclusion: There might be a certain correlation between AGT and myocardial hypertrophy in spontaneously hypertensive rats. T o inhibit the expression of AGT might like
ly provide a new method for the prevention and cure of patients with hypertension combined with myocardial hypertrophy.[Key words] Spontaneously hypertensive rats; Hypertension; Myocardial hypertrophy; Angiotensinogen [First-author’s address] Department of Respiratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao T ong University School of Medicine, Shanghai 200011, China.
作者简介袁丽粉，女,(1985- )，硕士，医师。上海交通大学医学院附属第九人民医院呼吸内
科，研究方向：呼吸内科。
昂立口译①上海交通大学医学院附属第九人民医院呼吸内科 上海 200011
②上海交通大学医学院附属第九人民医院老年病科 上海 200011马基雅维利主义
*通讯作者：wangjian0628@163 高血压引起的心血管疾病是中老年患者重要的 死亡原因之一。流行病学调查显示，在我国中老年患
者中高血压的患病率约为25%，其中近半数高血压患
武汉十五中张飞跃事件
者合并有心肌肥厚[1]。高血压是心肌肥厚发生发展的一个重要危险因素[2]。肾素-血管紧张素系统(renin- angiotensin system，RAS)在高血压以及心肌肥厚的
发生发展过程中起着重要的作用[3-4]。而血管紧张素原
(angiotensinogen，AGT)，作为RAS系统中的初始底
王华滔
物，直接控制着RAS系统活性的强弱[5]。为探索AGT
东芝as100
性高血压大鼠心肌肥厚与AGT的相关性研究。
1 材料与方法1.1 仪器与试剂(1)Nikon生物光学显微镜(日本Nikon公司)；CMl20透射电镜(荷兰飞利浦公司)；Powerlab/8SP生理信号采集与处理系统(澳大利亚AD Instruments，Castle Hill，NSM，Australia)；Chart多通道生理信号记录仪系统软件，全自动生化分析仪(美国DADE公司Dimension RXL)。(2)5%钠(中国医药集团上海化学试剂公司)；大鼠AGT ELISA试剂盒(美国R&D公司)；大鼠血管紧张素Ⅱ(angiotensin Ⅱ，AngⅡ)ELISA试剂盒路政传奇
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