英国卫生官员正敦促人们接种脊髓灰质炎（小儿麻痹症）疫苗，因为上个月该病毒在伦敦突然出现。今年2月，伦敦在例行废水监测中发现了一种脊髓灰质炎病毒株。这本身并不稀奇——或许有人在世界上仍然有该病毒传播的地方感染了。但在接下来的几个月里，同一毒株的变异版本再次被发现，这意味着该病毒已经出现人际传播（可能因为新冠疫情扰乱了正常的脊髓灰质炎疫苗接种）。不过，如果你住在受影响地区附近，也无需恐慌。目前还没有小儿麻痹症的病例报告，而且接种疫苗即可有效预防。公共卫生专家表示，重点是在低收入国家根除这种病毒，那里仍然有太多儿童的健康受其威胁。 What polio’s UK presence means for global health
汕头马会
A form of polio derived from the vaccine is probably circulating in the United Kingdom, highlighting the ongoing need for polio vaccination worldwide.
Polio samples were found in sewage in east London, less than 15 kilometres from the Tower of London (pictured), lit in purple to mark World Polio Day last October.Credit: PA Images/Alamy
UK health officials are urging people to make sure they are vaccinated against polio, after several sewage samples in London tested positive for the poliovirus towards the end of June.澳门特别行政区区旗的含义
The UK Health Security Agency (UKHSA), a public-health body, said a poliovirus strain was detected during routine surveillance of waste water in February. A mutated version of the same strain was picked up again in the following months, the agency added, suggesting the virus has spread between individuals, allowing it to evolve.
This virus is called vaccine-derived poliovirus. It is a strain of (weakened) poliovirus that would have originally been found in oral polio vaccines, but has changed over time to behave more like a wild type, or naturally occurring, poliovirus. Vaccine-derived poliovirus can spread through faeces or respiratory secretions. On rare occasions, it can infect the nervous system, causing paralysis and breathing problems in unvaccinated people.
No people with symptoms of polio — including paralysis — have been reported so far, but health authorities are asking doctors to look out for, and report, any symptoms of the dise
ase.
The last case of wild polio contracted in the United Kingdom was in 1984, and the country was declared polio-free in 2003, but the virus still circulates in some parts of the world. Nature explores what the resurgence of polio in the country means.
Why is there polio circulating in London sewers?
Traces of unrelated vaccine-like polioviruses are found every year in UK sewage samples. These detections typically occur when people vaccinated in other countries with a weakened form of the poliovirus return or travel to the country and shed the weakened live virus in their stool for a few weeks.美国地震局
tm2007However, the viruses detected since February are different. They were related to one another and contained mutations suggesting that the virus was spreading from person to person — probably through poor hand hygiene.
According to the UKHSA, there might have been some spread between “closely linked in
dividuals” who are now shedding the poliovirus strain in their faeces. “Investigations will aim to establish if any community transmission is occurring,” the agency said in a press release.
核酸染料Should people be alarmed?
Scientists say that, at the moment, there’s no reason to panic. The form of virus that was detected in waste water poses a low risk to health: vaccination easily prevents the disease it causes.
Children are routinely vaccinated against polio. According to the World Health Organization (WHO) Global Polio Eradication Initiative (GPEI), 86% of people in London are vaccinated against polio. However, a drop in vaccination uptake during the COVID-19 pandemic could allow the virus to keep circulating. A report this year by the UKHSA found that, in parts of west London, only 35% of teenagers had received their polio booster in 2020–21.
The COVID-19 pandemic has hindered routine vaccinations, which include polio immunization, says Kathleen O’Reilly, an epidemiologist at the London School of Hygiene & Tropical Medicine. The primary course of immunization against polio is combined with vaccinations against other diseases, such as tetanus and whooping cough, so children who missed their polio vaccination are probably vulnerable to other infectious diseases, O’Reilly says. “In some communities, [children] might have also missed the measles vaccine, so this is an early warning of other vaccine-preventable diseases potentially being a problem.”
The detection of vaccine-derived poliovirus in London, she adds, emphasizes the need to invest in vaccination efforts and the importance of wastewater surveillance.
Is polio on the rise globally?
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