MOOC遗传学Chapter 9-3

chapter outline chapter

主讲教师：王亚梅

9.1 Fragmenting DNA

• 9.2 Cloning DNA fragments • 9.3 Sequencing DNA • 9.4 Sequencing genomes • 9.5 Finding the genes in genomes • 9.6 Genome architecture and evolution

• 9.7 Bioinformatics: Information technology and genomes

n Looking for long open reading frames (开放阅读框,ORFs) in genomic DNA sequences.

n In any random sequence of DNA, there would be a

stop codon after about 64/3≈21 triplets.

n Useful but not perfect.

n By chance rarely contain a long ORF中国同性恋者

n Many genes are interrupted by introns, some exons

are so small

n Finding conserved DNA sequences

n The identification of genes in one organism facilitates

dpppthe identification of homologous genes in another

organism.

Species relatedness and genome conservation between

H. sapiens and other vertebrates

n Phylogenetic tree (系统进化树)

dce

n Branch points represent a series

of nested common ancestors

n Number at each branchpoint is

《产业结构调整指导目录(2011年本)》millions of years before the杨诗丽

数字化present

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