带状疱疹的临床特征及与他汀类药物关系的回顾性研究

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·论著·带状疱疹的临床特征及与他汀类药物关系的回顾性研究
袁媛,黄文祥,贾蓓*
【摘要】 背景 带状疱疹作为常见病毒感染性疾病,在体内病毒重新复活时可引起皮肤丘疹水疱,并可伴有神
经痛、带状疱疹眼病、继发感染等,严重影响患者生活质量。他汀类药物作为调脂药物,在临床中应用广泛。目前已
有研究证实带状疱疹的发生与他汀类药物的使用存在联系。目的 分析带状疱疹的临床特征,探讨带状疱疹发病与他
汀类药物使用的关系。方法 收集2014年11月—2016年11月于重庆医科大学附属第一医院住院并诊断为带状疱疹
患者731例作为带状疱疹组,同期收集非带状疱疹患者731例作为对照组。收集研究对象的一般资料,包括性别、年龄
切纸刀片吸烟史、饮酒史、体质指数(BMI)、血脂水平、合并症、他汀类药物和抗血小板凝集药物使用情况、脂肪肝发生情家用电动绞肉机
况。分析带状疱疹患者的性别、年龄分布,带状疱疹与烟酒史、BMI、血脂水平、合并症、他汀类药物和抗血小板凝
集药物使用情况的关系。将带状疱疹组根据患者年龄分为≤30岁亚组49例、31~60岁亚组261例、>60岁亚组421例,
比较各亚组带状疱疹发病的特点。结果 带状疱疹组他汀类药物使用率高于对照组(P<0.05)。带状疱疹组患者中,活性炭脱硫剂
有合并症患者446例(61.0%),其中存在2种及以上合并症228例(51.1%)。常见的合并症是高血压242例(54.3%)
及糖尿病134例(30.0%)。不同年龄亚组患者带状疱疹发生率比较,差异有统计学意义(P<0.05)。>60岁亚组合
并高血压、除外高血压的其他心血管疾病、脑卒中发生率、他汀类药物使用率高于≤60岁亚组(P<0.05);31~60岁
太白参亚组合并糖尿病发生率高于≤30岁亚组(P<0.05);≤30岁亚组合并肿瘤发生率高于31~60岁亚组和>60岁亚组
(P<0.05);31~60岁亚组合并结缔组织病发生率低于≤30岁亚组,但高于>60岁亚组,≤30岁亚组合并结缔组织
病发生率高于>60岁亚组(P<0.05)。结论 带状疱疹的发生可能与年龄增长及服用他汀类药物有关。
【关键词】 带状疱疹;临床特征;他汀类药物
【中图分类号】 R 752.12 【文献标识码】 A DOI:10.3969/j.issn.1007-9572.2018.00.122
袁媛,黄文祥,贾蓓.带状疱疹的临床特征及与他汀类药物关系的回顾性研究[J].中国全科医学,2018,21(21):2587-2591.[www.chinagp]
YUAN Y,HUANG W X,JIA B.Clinical features of herpes zoster and its correlation with statins usage[J].Chinese General Practice,2018,21(21):2587-2591.
Clinical Features of Herpes Zoster and Its Correlation with Statins Usage YUAN Yuan,HUANG Wen-xiang,JIA Bei* Department of Infectious Diseases,the First Affiliated Hospital of Chongqing Medical University/Key Laboratory of Infectious and Parasitic Diseases in Chongqing,Chongqing 400016,China
阻尼电机yig滤波器*Corresponding author:JIA Bei,Professor,Master supervisor;E-mail:beijia2008@yeah
【Abstract】 Background Herpes zoster is a common infectious disease caused by reactivation of varicella zoster
virus.This disease may lead to papule blister,and may be accompanied by neuralgia,herpes zoster ophthalmicus,secondary infection,etc,seriously impairing the patient's quality of life.Statins are widely used in clinical practice as a lipid-regulating
drug.Several studies have confirmed that herpes zoster is associated with the use of statins.Objective To analyze the clinical characteristics of herpes zoster and to explore the relationship between herpes zoster and the use of statins.Methods The enrolled 1462 inpatients were all from the First Affiliated Hospital of Chongqing Medical University from November 2014 to November 2016,including 731 with herpes zoster(herpes zoster group),and 731 without herpe
s zoster(control group).Demographic
and clinical data,including gender,age,smoking history,drinking history,body mass index(BMI),lipid levels,comorbidities,and use of statins and antiplatelet aggregation drugs were collected.The prevalence of herpes zoster by gender
and age,the relationship of herpes zoster with smoking and drinking history,BMI,lipid level,comorbidities,use of statins
and antiplatelet agglutination drugs were analyzed.The herpes zoster patients were divided into≤ 30-year-old subgroup(49 cases),31-60-year-old subgroup(261 cases),and > 60-year-old subgroup(421 cases),then their characteristics were compared.Results The use rate of statins in herpes zoster group was higher than that of the control group(P<0.05).Among 400016重庆市,重庆医科大学附属第一医院感染科 重庆市传染病寄生虫病学重点实验室
*通信作者:贾蓓,教授,硕士生导师;E-mail:beijia2008@yeah

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