丁苯酞序贯疗法对急性脑梗死的临床疗效及血清白细胞介素-6、金属

丁苯酞序贯疗法对急性脑梗死的临床疗效及血清白细胞介素-6㊁金属基质蛋白酶-2㊁金属基质蛋白酶-9的影响

范道丰，胡职舟，潘丽英，郑　冲，胡小红，陈银娟，陈衍贵　(福建医科大学附属龙岩第一医院神经内科，福建　龙岩　364000)

基金项目：福建省龙岩市科技局基础研究和公益类项目[项目编号:2016LY54]；福建省自然科学基金项目[项目编号:2018J0105]通讯作者：陈衍贵[摘　要]　目的：探讨丁苯酞序贯疗法对急性脑梗死的临床疗效及血清白细胞介素6(IL-6)㊁金属基质蛋白酶-2(MMP-2)㊁金属基质蛋白酶-9(MMP-9)的影响㊂方法：选取急性脑梗死患者，按随机数字表法，将80例急性脑梗死患者随机分为两组，对照组(40例)在常规组，序贯组(40例)为常规上加用丁苯酞注射液，14d 后，使用丁苯酞软胶囊至第90天㊂于前㊁7d ㊁14d ㊁90d 检测两组患者血清IL-6㊁MMP-2㊁MMP-9的变化，对比两组患者运用不同干预方法的临床效果㊂结果：序贯组在7d ㊁14d ㊁90d 时，血清IL-6㊁MMP-2㊁MMP-9水平较对照组明显降低，差异有统计学意义(P <0.05)；运用不同方法干预90d 后，序贯组患者的有效率为97.5%，显著高于对照组(85.0%)，两组数据比较，差异有统计学意义(P <0.05)；序贯组患者的NIHSS ㊁ADL 评分优于对照组，两组数据比较差异有统计学意义(P <0.05)㊂结论：急性脑梗死患者运用丁苯酞序贯疗法干预可显著降低患者IL-6㊁MMP-

弹簧包

2㊁MMP-9的水平，提高了患者的生活能力及神经功能水平㊂[关键词]　丁苯酞序贯疗法；急性脑梗死；白细胞介素；金属基质蛋白酶

The effect of butylphthalide sequential therapy on acute cerebral infarction and its effect on serum IL -6㊁MMP -2and MMP -9 FAN Dao -feng ,HU Zhi -zhou ,PAN Li -ying ,et al (Department of Neurology ,The Frist Affiliated Longyan Hospital of Fujian Medical University ,Longyan 364000,China .)

启动电容器Abstract :Objective To investigate the clinical efficacy of butylphthalide sequential therapy for acute cerebral infarction and to study the effects on serum IL-6㊁MMP-2and MMP-9.Method 80cases of acute cerebral infarction patients were ad⁃mitted to our hospital,according to the method of random,the patients were divided into contral group (40cases)with conven⁃tional therapy and se-quential therapy group (40cases)with Conventional treatment plus Butylphthalide injection for 14days,and then use Butylphthalide Soft Capsules to 90days.The le-vels of serum IL-6,MMP-2and MMP-9in 2groups were detec⁃ted before treatment,7days,14days and 90days after treatment and the clinical effects of different interventions were com⁃pared between the two groups.Results The serum IL-6,MMP-2and MMP-9levels in the sequential group were significantly lower than those in the cont-rol group on the 7day,the 14day and the 90day after treatment,two groups of data showed s

ignif⁃icant difference(P <0.05).Patients were treated with different methods for 90days,the effective rate of 97.5%of sequential group was significantly higher than that of control group 85.0%,two groups of data showed significant difference (P <0.05);The NIHSS and ADL scores in sequential group were better than those in the control group,there was a significant difference in the comparison between the two groups (P <0.05).Conclusion The use of butylphthalide sequential therapy in patients with acutecerebral infarction can significantly reduce the level of IL-6,MMP-2and MMP-9,and improve the patient's ability to live and the level of nerve function.Key Words :Butylphthalide sequential therapy;Acute cerebral infarction;Interleukin;Matrix metalloproteinase

脑梗死在卒中中占比例高，其有发病率㊁致残率㊁致死率高的特点，严重危及到居民生活健康㊂既往研究表明白细胞介素6(interleukin-6,IL-6)㊁金属基质蛋白酶-2(matrix met⁃alloproteinases-2,MMP-2)和金属基质蛋白酶-9(matrix metal⁃loproteinases-9,MMP-9)在脑梗死发生㊁发展中发挥重要作用[1-2]㊂丁苯酞为‘中国缺血性脑血管疾病指南“推荐的有效药物，能有效改善急性脑梗死患者的预后[3]㊂但丁苯酞

玻璃钢套管

序贯对急性脑梗死生活能力㊁神经功能影响及对IL-6㊁MM-2㊁MMP-9的研究较少㊂本研究在于探讨丁苯酞序贯治

保健油疗对急性脑梗死生活能力㊁神经功能的影响及对血清IL-6㊁

雨生红球藻养殖MMP-2㊁MMP-9的影响㊂㊃9961㊃吉林医学2019年8月第40卷第8期

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