Product Name:
Cycloheximide CAS No.:
66-81-9Cat No :HY-12320Product Data Sheet
Cat. No.:
HY 12320MWt:
281.35Formula:
C15H23NO4Purity :>98%
j biol chem
Solubility:Mechanisms:
Biological Activity:
颠簸的
航行Pathways:Anti-infection; Target:Antifungal DMSO:32mg/mL Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM.
IC50 value: 532.5 nM
Target: Antifungal Cycloheximide is a highly effective antibiotic with activity against mold, yeast, and phytopathogenic fungi, with lower activity against bacteria. It has been reported to inhibit the synthesis of both proteins and macromolecules, as well as affect apoptosis in eukaryotes. Inhibition of protein synthesis is believed to be mediated through DNA translation arrest, as demonstrated in rat thymocytes. Cycloheximide has also been reported to inhibit FKBP12 (peptidylprolylisomerase射频
调制器 hFKBP12PPIase hFKBP12)via competitive inhibition Cycloheximide exerts its effect by interfering References:
耳光室lanm[1]. Schneider-Poetsch T, et al. Inhibition of eukaryotic translation elongation by cycloheximide and
lactimidomycin. Nat Chem Biol. 2010 Mar;6(3):209-217.[2]. Fischer-Posovszky P, Keuper M, Nagel S, et al. Downregulation of FLIP by cycloheximide iti h f t ll t CD95i d d t i E i t l ll h 2011317(15)hFKBP12, PPIase hFKBP12) via competitive inhibition. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome) thus blocking
saba-018sensitizes human fat cells to CD95-induced apoptosis. Experimental cell research, 2011, 317(15):
2200-2209.[3]. Park W S, Sung D K, Kang S, et al. Therapeutic window for cycloheximide treatment after
hypoxic-ischemic brain injury in neonatal rats. Journal of Korean medical science, 2006, 21(3): 490-
494.Caution: Not fully tested. For research purposes only
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