国产猪抗人淋巴细胞球蛋白联合环孢素重型再生障碍性贫血的效果t载体
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加密代理>抗生素制作方法 目的 探讨国产猪抗人淋巴细胞球蛋白（p-ALG）联合环孢素重型再生障碍性贫血（SAA）的效果及安全性。 方法 分析2004年4月～2016年12月江苏省连云港市第一人民医院血液科应用国产p-ALG联合环孢素30例SAA患者的有效性、安全性并长期随访统计分析五年生存率。 结果 30例SAA患者中位年龄为26.5（5～65）岁，随访中位时间为60（1～252）个月，6例死亡，总有效率为73.3%，中性粒细胞>0.5×109/L，中位时间为20（2～40）d，脱离红细胞输注的中位时间为30（0～150）d，脱离血小板输注的中位时间为35.5（5～140）d。五年生存率达78%，不良反应均能耐受，花费少。 结论 国产p-ALG联合环孢素SAA的长期效果显著，不良反应轻微，值得临床推广。接菜
[Abstract] Objective To analyze the efficacy and safety of Pig Anti-Human Lymphocyte Globulin combined with Cyclosporin in the treatment of severe aplastic anemia. Methods A total of 30 cases hospitalized in Department of Hematology， the First People′s Hospital of Lianyungang City， Jiangsu Province from Apirl 2004 and December 2016 were enrolled into this study. The efficacy and safety of this treatment were analyzed， the overall surviva
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l by Kaplan-Meier method for this cohort of patients were estimated. Results The cohort of 30 patients was routinely followed up with a median follow-up of 60 （1-252） months， the median age was 26.5 （5-65） years old. Six died， the over response rate was 73.3%. The median time of the ANC>0.5×109/L was 20 （2-40） days， transfusion of red blood cell independent was 30 （0-150） day， transfusion of palete independent was 30 （0-150） days， the 5-year survival rate was 78%. The response rate was high， but with less side effects and expense. Conclusion Long-term effect of Pig Anti-Human Lymphocyte Globulin combined with Cyclosporin in the treatment of severe aplastic anemia is significant， adverse reactions are mild， it is worthy of clinical promotion.
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