联合签名A Role for Bone Morphogenetic Protein-4 in0663.us
Adipocyte Development
期刊名称： Cell Cycle
作者： Robert R Bowers,M Daniel Lane
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年份： 2007年
期号： 第4期
关键词： Adipocytes;Bone Morphogenetic Proteins；脂细胞；骨形态发生蛋白质类 摘要：Obesity is characterized by increases in the number of mature adipocytes. Nascent adipocytes arise from mesenchymal stem cells (MSCs) by a multi-step process MSCs are recruited to the adipocyte lineage forming determined preadipocytes, these committed progenitors proliferate, undergo growth arrest, and finally differentiate into mature adipocytes. Although the genetic mechanisms that co发光片
发光片ntrol the differentiation of preadipocytes into mature adipocytes are understood to a large extent, the earliest events in adipogenesis especially the commitment of MSCs into preadipocytes are largely unknown. Recently, bone morphogenetic protein-4 (BMP-4) has been implicated in the commitment of pluripotent MSCs to the adipocyte lineage by two independent lines of investigation. First, growth-arrested 10T1/2 cells do not normally respond to
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