Enzymes | E.C. Number | Cleavage sites |
Serine proteases | E.C.3.4.21. | |
E.C.3.4.21.1 | Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, and also Leu-|-Xaa, Met-|-Xaa, | |
Trypsin (胰朊酶,胰蛋白酶) | E.C.3.4.21.4 | Arg-|-Xaa, Lys-|-Xaa, |
E.C.3.4.21.36 | Ala-|-Xaa,and also Gly-|-Xaa, Val-|-Xaa, Ser-|-Xaa, | |
Thrombin(凝血酶) | E.C.3.4.21.5 | Arg-|-Gly, |
E.C.3.4.21.7 | Lys-|-Xaa,> Arg-|-Xaa | |
Prolyl oligopeptidase,or prolyl endopeptidase | E.C.3.4.21.26 | Pro-|-Xaa,>> Ala-|-Xaa |
E.C.3.4.21.34 | Arg-|-Xaa, Lys-|-Xaa,including Arg-|-Ser, Lys-|-Arg, | |
Leukocyte elastase(白细胞弹性蛋白酶 ),or neutrophil elastase(中性白细胞弹性蛋白酶),or lysosomal elastase(溶酶体弹性蛋白酶) | E.C.3.4.21.37 | Val-|-Xaa, Ala-|-Xaa, |
Cysteine proteases | E.C.3.4.22. | |
Cathepsin B(组织蛋白酶) | E.C.3.4.22.1 | Arg-Arg-|-Xaa, and also Leu-|-Xaa, Ala-|-Xaa, Phe-|-Xaa, Trp-|-Xaa, |
Clostripain(梭菌蛋白酶),or endoproteinase Arg-C | E.C.3.4.22.8 | Arg-|-Xaa including Arg-|-Pro,but not Lys-|-Xaa |
Calpain(钙激活中性蛋白酶)-1,or μ-calpain | 回程间隙 E.C.3.4.22.52 | Met-|-Xaa, Tyr-|-Xaa and Arg-|-Xaa(with Leu or Val as the P2 residue) |
Aspartic acid proteases | E.C.3.4.23. | |
Pepsin(胃朊酶,胃蛋白酶) | E.C.3.4.23.1 | Preferentially Phe-|-Xaa, Tyr-|-Xaa, and also Leu-|-Xaa,and Trp-|-Xaa,,ideally with Xaa= Phe,Trp,or Tyr |
Cathepsin(组织蛋白酶)D | E.C.3.4.23.5 | Preferentially Phe-|-Xaa, Tyr-|-Xaa, and also Leu-|-Xaa, ideally with Xaa ≠ Ala or Val |
Metalloproteases | E.C.3.4.24. | |
Neprilysin(脑啡肽酶),or enkephalinase(脑啡肽酶),or neutral endopeptidase | E.C.3.4.24.11 | Xaa-|-Tyr, Xaa-|-Phe, Xaa-|-Trp, and Xaa-|-Leu, |
丙酮回收Thimet oligopeptidase(甲拌磷寡肽酶),or endo-oligopeptidase A,or endopeptidase(肽链内切酶)24.15,or pz-peptidease(肠促胰酶素) | E.C.3.4.24.15 | Xaa-|-Arg, Xaa-|-Ser, Xaa-|-Ile, Xaa-|-Ala, Xaa-|-Gly, | 铜锌合金
Aminopeptidases | E.C.3.4.11. | N-term |
Leucyl-aminopeptidase | E.C.3.4.11.1 | 止水针头Preferentially Leu-|-Xaa,but not Arg-|-Xaa,and Lys-|-Xaa, |
Aminopeptidase M or N,or alanyl- aminopeptidase,or membrane alanine aminopeptidase | E.C.3.4.11.2 | Preferentially Ala-|-Xaa,and Tyr-|-Xaa,if Yaa-Pro-|-Xaa in term with Yaa = Ala,Val,Leu,Ile,Phe,Tyr or Trp,then the dipeptide Yaa-Pro could be released |
Aminopeptidase B | E.C.3.4.11.6 | Arg-|-Xaa, Lys-|-Xaa, |
Aminopeptidase A,or angiotensinase,or glutamyl-aminopeptidase | E.C.3.4.11.7 | Glu-|-Xaa>> Asp-|-Xaa, |
Dipeptidyl-peptidases and tripeptidyl-peptidases | E.C.3.4.14. | N-term(di-and tripeptides) |
Dipeptidyl-peptidase I,or cathepsin(组织蛋白酶) C or J | E.C.3.4.14.1 | Xaa-Yaa-|-Zaa,if Xaa ≠ Arg or Lys,or Yaa ≠ Pro,or Zaa ≠ Pro |
Dipeptidyl-peptidase IV | E.C.3.4.14.5 | Preferentially Xaa-Pro-|-Zaa,(but also Xaa-Ala-|-Yaa) with Yaa ≠ Pro or Hyp |
Prolyl tripeptyl-peptidase | E.C.3.4.14.12 | Xaa-Yaa-Pro-|-Zaa,if Zaa ≠ Pro |
Peptidyl-Dipeptidases | E.C.3.4.15. | C-term |
Peptidyl-depeptidase A, or angiotensin-converting enzyme | E.C.3.4.15.1 | Xaa-|-Yaa-Zaa,if Yaa ≠ Pro or Zaa ≠ Asp or Glu |
Metallo-carboxypeptidases | E.C.3.4.17. | C-term |
Carboxypeptidase A | E.C.3.4.17.1 | Xaa-|-Yaa if Yaa ≠ Asp,Glu,Arg,Lys or Pro |
Carboxypeptidase B,or protaminase | E.C.3.4.17.2 | Xaa-|-Arg and Xaa-|-Lys |
Carboxypeptidase N,or Lysine(arginine), Carboxypeptidase(羧基肽酶),or kininase I(激肽酶) | E.C.3.4.17.3 | Xaa-|-Lys>> Xaa-|-Arg |
Carboxypeptidase U or R | E.C.3.4.17.20 | Xaa-|-Arg and Xaa-|-Lys |
Glutamate Carboxypeptidase II,or folate hydrolase | E.C.3.4.17.21 | Xaa-|-Glu,preferentially with Xaa= Asp or Glu |
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