缎纹织物
• 406 • http ； //www. chinagp. net E-mail ； z^qkyx@ chinagp. net, cn (SIP Chinese General Practice
D e c e m b e r 2016，V o l, 19
•论著••中医•中西医结合研究•心脑欣慢性肺源性心脏病患者的临床疗效及机制研究苟连平，刘世平，方志远 【摘要】 目的观察中成药心脑欣慢性肺源性心脏病（肺心病）患者的临床疗效，并分析其机制。方法 选取2014年1月一2015年2月在川北医学院附属医院就诊的慢性肺心病患者100例，采用随机数字表法分为常规组和 心脑欣组，每组50例。另选取同期体检健康志愿者50例作为对照组。常规组给予常规，心脑欣组在常规基 石出上加服心脑欣丸，对照组不。比较常规组与心脑欣组前及4周后血气分析指标〔动脉血氧分压 (P a 02)、动脉血二氧化碳分压（PaC02)、血氧饱和度（Sa02)〕、N Y H A 分级，比较常规组与心脑欣组血气分析指标、 临床症状/特征好转时间和临床疗效。比较对照组、常规组、心脑欣组血浆内皮素（E T )、脑钠肽（B N P )、红细胞生 成素（E P 0)水平。结果常规组、心脑欣组患者前Pa02、PaC02、Sa02、N Y H A 分级比较，差异无统计学意义 (P >0.051_常规组患者后Pa02、Sa02均低于心脑欣组，N Y H A 分级高于心脑欣组（P <0.05)a 常规组患者血气 手动加油泵
分析指标、临床症状/特征好转时间均长于心脑欣组（P <〇.〇5) q 心脑欣组患者临床疗效优于常规组（u =2.67，P < 0.05)s 常规组、心脑欣组前及后血浆E T 、B N P 水平均高于对照组，血浆E P 0水平均低于对照组（P < 0.01)。后常规组和心脑欣组血浆E T 、B N P 水平均低于前，血浆E P 0水平均高于前（P <0.01)Q 结论 心脑欣丸慢性肺心病临床疗效显著，其机制可能与降低血浆E T 、B N P 水平，升高血浆E P 0水平有关。
【关键词】 肺心病；心脑欣；结果
美容器具【中图分类号】R 541. 5袜子定型机
亮晶晶眼贴【文献标识码】A Efficacy and Mechanism of Xinnaoxinwan on Chronic Corpulmonale GOU Lian - ping, LIU Shi - p ing, FANG Zhi - yuan. Department o f Cardiovascular, Affiliated Hospital o f North Sichuan Medical College, Nanchong 637000, China Corresponding autor ： FANG Zhi - yuan，Department of Pharmacy，Shaanxi Provincial People's Hospital, X i a n 710068 , China
【Abstract 】 Objective To observe the efficacy of xinnaoxin in treating chronic pulmonary heart disease, and analysis of its mechanism. Methods 100 cases of chronic pulmonary heart disease in A
ffiliated Hospital of North Sichuan Medical College from January 2014 to February 2015 were selected. They were divided into the routine group and xinnaoxin group by using the method of random number ta b le , 50 cases in each group. Another 50 cases of healthy volunteers were selected as the control group. Routine group was given conventional treatm ent, the xinnaoxin group was given xinnaoxin based on routine group, and the control group was not treated. Blood gas index ( Pa02, PaC02, Sa02 ) and N Y H A classification before and 4 weeks after treatment in the routine group and xinnaoxin group were compared. The blood gas in d e x, clinical symptom / characteristic improvement time and clinical curative effect were compared between routine group and xinnaoxin group. E T, BNP and EPO were compared in the control group, routine group and xinnaoxin group. Results Pa02, Pa02, Sa02 and N Y H A were not significantly different between the two groups (P > 0. 05). The Pa02 and Sa02 in routine group were lower than that of xinnaoxin group, N YH A class was higher than that of xinnaoxin group ( P < 0. 05 ). The blood gas index and clinical symptoms and improvement of patients in routine group were longer than those in xinnaoxin group (P < 0. 05). The clinical curative effect of xinnaoxin group was better than that of routine group (u = 2. 61, P <0. 05 ). The ET and BNP of the routine group and xinnaoxin group before and after treatment were higher than those in the control group, EPO was lower than that of the control group (P < 0. 01). After treatm ent, ET and BNP in the routine group and xinnaoxin group were lower than those before treat
m ent, EPO was higher than those before treatment (P < 0. 01 ). Conclusion The therapeutic effect of xinnaoxin on chronic pulmonary heart disease is remarkable. The mechanism may be related to the decrease of plasma ET and BNP levels and the increase of plasma 作^咻位：637000四川省南充市，川北丨欠f 院附属医院心内科（符迮平），总诊科（刘世平）；陕西省人民医院药剂科（方志 远）
固体水通倍作I 方志远，710000陕西省西安市，陕西省人民医院药剂科；E -m a il: fangZ hy300@ 163. 6〇m EPO
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