Product Name:
Pyridostatin CAS No.:
1085412-37-8Cat. No.:
HY-15176
Product Data Sheet
tps5430MWt:
596.64Formula:
C31H32N8O5Purity :>98%
Solubility:
DMSO
Mechanisms:
Biological Activity:
Pyridostatin(RR-82)is a G-quadruplex-interacting drug which can promote growth arrest in human Pathways:Cell Cycle/DNA Damage; Target:G-quadruplex Pyridostatin(RR-82) is a G-quadruplex-interacting drug which can promote growth arrest in human
cancer cells by inducing replication- and transcription-dependent DNA damage.
IC50 Value:
Target: G-quadruplex in vitro: The increased mechanical stability of pyridostatin-bound G-quadruplex permits the
determination of a dissociation constant K(d) of 490 ± 80 nM. The free-energy change of binding obtained from a Hess-like process provides an identical K(d) for pyridostatin and a K(d) of 42 ± 3 ?M for a weaker ligand RR110 [1]. Pyridostatin reduced SRC protein abundance and SRC-dependent
cellular motility in human breast cancer cells, validating SRC as a target of this drug [2].References:
[1]. Koirala D, Dhakal S, Ashbridge B, A single-molecule platform for investigation of interactions
陶瓷滤波器between G-quadruplexes and small-molecule ligands. Nat Chem. 2011 Aug 28;3(10):782-7.[2]. Rodriguez R, Miller KM, Forment JV, Small-molecule-induced DNA damage identifies alternative
in vivo:
Clinical trial: N/A ...
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DNA structures in human genes. Nat Chem Biol. 2012 Feb 5;8(3):301-10.Caution: Not fully tested. For research purposes only
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