j biol chemPathophysiology of DIC in obstetric disorders
产科DIC的病理生理学
搅拌头
It is important to understand the normal coagulation process in order to characterise the abnormalities observed during DIC.
为了描述DIC的异常特征,理解正常的凝血过程十分重要。 1. The coagulant response begins with exposure of tissue factor (TF) and binding of factor VIIa to activate factor X for conversion of pro-thrombin to thrombin.无线数据传输[1]
凝血反应始于组织因子(TF)的暴露以及VIIa与Xa结合使凝血酶原转变为凝血酶快装脚手架
[1
]。 2. Thrombin generation is further propagated through the intrinsic pathway and the explosive burst of thrombin results in cleavage of fibrinogen into fibrin.[2]
凝血酶通过内源性途径进一步生成,凝血酶的爆发式生成导致了纤维蛋白原裂解为纤维蛋白[2
]。 3. 一叶荻Clot formation is homeostatically regulated to achieve the desired haemostatic effect and this involves a number of regulatory responses that are spatially and temporally differentiated.
血块的形成是自稳性调节而获得理想的止血效果,这涉及了大量的时空特异性的调解节反应。 4. Normal endothelium at the margins of injury switches from thrombin procoagulant to anticoagulant activity via its binding to the endothelial receptor, thrombomodulin (TM).超滤器[3]