首页 > 专利学习

环磷腺苷葡胺联合低温可调钠透析透析中低血压的临床疗效研究

·1805·

www.chinagp E-mail:zgqkyx@chinagp ·论著·环磷腺苷葡胺联合低温可调钠透析透析中

低血压的临床疗效研究

濮红梅1，冯锦红2*，刘秉成2，徐静1

【摘要】　目的　观察环磷腺苷葡胺（MAC）联合低温可调钠透析（LSHD）透析中低血压（IDH）的临床疗效。

方法　选取2015年6—12月徐州医科大学附属医院和徐州医科大学附属第三医院血液净化中心符合纳入标准的复发

性IDH患者28例为研究对象。患者先后采用3种方法〔常规血液透析（CHD）、LSHD、MAC联合LSHD（M-LSHD）〕

进行，各8周，每周3次。记录3种方法过程中患者血压的变化和低血压发生率，检测每种方法最

后1次透析前与透析后电解质（K+、Na+、Ca2+）、尿素氮、血肌酐、Ｎ末端前体B型钠尿肽（NT-proBNP），观察

不良反应发生情况。结果　3种方法患者透析前收缩压、舒张压比较，差异无统计学意义（P>0.05）；M-LSHD

患者透析中最低收缩压、舒张压高于CHD、LSHD，低血压发生率低于CHD、LSHD（P<0.05）。3种方法

最后1次透析前、后K+、Na+、Ca2+、尿素氮、血肌酐比较，差异无统计学意义（P>0.05）；M-LSHD透析前、后

NT-proBNP均低于CHD、LSHD（P<0.05）。患者均未出现因低温引起的畏寒、寒战等不耐受现象；MCA静脉注射未见心悸、

头晕等药物不良反应发生。结论　M-LSHD通过改善IDH患者的心功能，可明显减少IDH的发生，无明显不良反应，

有临床推广价值。

血氧仪测试方法【关键词】　低血压；血液透析液；强心药

【中图分类号】　R 544.2　【文献标识码】　A　DOI：10.3969/j.issn.1007-9572.2017.00.225

濮红梅，冯锦红，刘秉成，等．环磷腺苷葡胺联合低温可调钠透析透析中低血压的临床疗效研究［J］．中

国全科医学，2018，21（15）：1805-1808．［www.chinagp］

PU H M，FENG J H，LIU B C，et al．Clinical efficacy of meglumine adenosine cyclophosphate combined with low temperature adjustable sodium hemodialysis for intradialytic hypotension［J］．Chinese General Practice，2018，21（15）：1805-1808．

Clinical Efficacy of Meglumine Adenosine Cyclophosphate Combined with Low Temperature Adjustable Sodium Hemodialysis for Intradialytic Hypotension　PU Hong-mei1，FENG Jin-hong2*，LIU Bing-cheng2，XU Jing1

有起子1.Department of Nephrology，the Third Affiliated Hospital of Xuzhou Medical University，Xuzhou 221003，China

2.Department of Nephrology，Affiliated Hospital of Xuzhou Medical University，Xuzhou 221006，China

静电消除装置

尼龙扣*Corresponding author：FENG Jin-hong，Associate chief physician；E-mail：feng_jh@189交换目录

【Abstract】　Objective　To investigate the clinical efficacy of meglumine adenosine cyclophosphate（MAC） combined

with low temperature adjustable sodium hemodialysis（LSHD） for intradialytic hypotension（IDH）．Methods　We enrolled

28 patients with recurrent IDH who were admitted to the Blood Purification Center，Affiliated Hospital of Xuzhou Medical University and the Third Affiliated Hospital of Xuzhou Medical University from June to December 2015 and who met the inclusion criteria.All patients underwent either conventional hemodialysis（CHD），LSHD，or MAC combined with LSHD（M-LSHD）

three times a week for 8 weeks，respectively.Changes in blood pressure and the incidence of hypotension were recorded during hemodialysis.Electrolyte（K+，Na+，Ca2+），serum urea nitrogen，serum creatinine，and N-terminal pro-brain natriuretic

peptide（NT-proBNP） levels were also measured，and adverse effects were observed before and after the final hemodialysis for

each treatment.Results　There was no significant difference in systolic or diastolic blood pressure prior to hemodialysis among the

three treatments（P>0.05）．The lowest systolic and diastolic blood pressures during hemodialysis were significantly greater and

the incidence of hypotension was significantly lower in patients undergoing M-LSHD compared with CHD or LSHD（P<0.05）．

There were no significant differences in serum K+，Na+，Ca2+，urea nitrogen，or creatinine levels between before and after the

final hemodialysis for each treatment（P>0.05），but NT-proBNP levels were significantly lower in patients undergoing M-LSHD compared with the other procedures both before and after hemodialysis（P<0.05）．In addition，no patients showed intolerance

微型弹簧

1.221003江苏省徐州市，徐州医科大学附属第三医院肾内科

2.221006江苏省徐州市，徐州医科大学附属医院肾内科

*通信作者：冯锦红，副主任医师；E-mail：feng_jh@189

本文发布于:2024-09-20 20:33:12，感谢您对本站的认可！

本文链接：https://www.17tex.com/tex/1/235649.html

上一篇：maya白金手册

下一篇：众路线在高校体性事件防治中的作用及实现机理研究