专利名称：Oligosaccharide oxazolines, oligosaccharide conjugates and methods of preparation thereof
发明人：Colon, Marcelo,Rasmussen, James R.,Davis, Jeffrey T.,Borowski, Marianne,Wan, Barabara
Y.,Hirani, Shirish
申请号：EP98104031.4
申请日：19910524
干电池手机
公开日：m6co
19980826模压制品
专利内容由知识产权出版社提供手结构图
摘要：This invention relates to a method of producing peracetyloxazolines from peracetyl saccharides. The method involves reacting the starting material, a peracetyl saccharide, with a reagent combination, to directly produce the peracetyl oxazoline. This method may be used for the activation of oligosaccharides, wherein an oligosaccharide containing a reducing GlcNAc terminus is activated by the formation of an oxazoline at the terminal GlcNAc, and then coupled with a bifunctional spacer to provide an oligosaccharide-spacer conjugate. The activated oligosaccharide-spacer conjugate is then coupled to a protein, such as granulocyte colony stimulating factor or γ-interferon, providing a neoglycoprotein conjugate. The invention provides a method for forming neoglycoprotein conjugates which may improve biological and physiochemical properties of the protein. For example, serum life-time or efficiency of drug delivery of the peptide to a target organ or cell may be improved.时钟显示器
申请人：GENZYME CORPORATION
地址：One Kendall Square Cambridge, Massachusetts 02139 US 国籍：US
代理机构：Atkinson, Jonathan David Mark
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