电容耐压测试仪
DLX6-AS1 promotes cell proliferation, migration and EMT of gastric cancer through FUS-regulated
MAP4K1阳光天井
期刊名称： Cancer biology & therapy数据线接头
作者： Qiong Wu,Jiali Ma,Wenying Meng,Pingping Hui
年份： 2019年
期号： 第1期
关键词： Gastric cancer (GC);lncRNA DLX6-AS1;MAP4K1;FUS
摘要：Gastric cancer (GC) is the second most prevalent carcinoma resulting in cancer-related deaths in the world, with differences among geographic areas. Although the incidence and mortality rates of GC in Asia are decreasing, the search for diverse and effective therapies of GC is still needed to be fully inquired. The present research explored the expression pattern, functional role and underlying me
chanism of DLX6-AS1 in GC. Firstly, we measured DLX6-AS1 expression in GC and then found the elevated level of DLX6-AS1. To further inspect the function role of DLX6-AS1 involved in GC, we performed lost-of-function assays. The silencing of DLX6-AS1 suppressed cell proliferation, migration and EMT process of GC cells. Subsequently, we uncovered that MAP4K1 was also up-regulated in GC and could be positively regulated by DLX6-AS1. Moreover,...
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